Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730519 | 0.91 | ABCG2 (0.45) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4725979 | 0.89 | MAPK14 (0.43) | RAF1BRAFMAPK14HSPB1LYN | |
| SCHEMBL4728336 | 0.85 | MAPK14 (0.39) | RAF1BRAFMAPK14 | |
| SCHEMBL4783017 | 0.85 | MAPK14 (0.41) | RAF1BRAFMAPK14 | |
| SCHEMBL4728099 | 0.85 | RAF1 (0.41) | RAF1BRAFMAPK14HSPB1LYN | |
| SCHEMBL4727320 | 0.85 | CNR2 (0.42) | RAF1BRAFMAPK14 | |
| SCHEMBL4727004 | 0.85 | RAF1 (0.43) | RAF1BRAFMAPK14 | |
| SCHEMBL4730324 | 0.84 | MAPK14 (0.42) | RAF1BRAFMAPK14 | |
| SCHEMBL4728030 | 0.84 | MAPK14 (0.42) | RAF1BRAFMAPK14 | |
| SCHEMBL4726017 | 0.84 | CCNT1 (0.41) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |