Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14221428 | 0.89 | KMT2A (0.59) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL27923742 | 0.88 | MEN1 (0.64) | NPC1RAB9AMEN1KMT2AKCNK3 | |
| SCHEMBL1454747 | 0.88 | MEN1 (0.68) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL11244847 | 0.85 | ALDH1A1 (0.76) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL8301169 | 0.85 | MEN1 (0.58) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL8303947 | 0.84 | ALDH1A1 (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18941246 | 0.83 | NPC1 (0.66) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL2567642 | 0.82 | MEN1 (0.77) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL1663381 | 0.82 | RAB9A (0.59) | NPC1RAB9AMEN1KMT2AKCNK3 | |
| SCHEMBL4253852 | 0.80 | MAPT (0.72) | NPC1RAB9AHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |