Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728717 | 0.95 | RAB9A (0.52) | RAB9ATP53HTTSMN1; SMN2NPC1 | |
| SCHEMBL4729633 | 0.75 | EGFR (0.51) | RAB9ATP53HTTSMN1; SMN2NPC1 | |
| SCHEMBL4726716 | 0.75 | RAB9A (0.46) | RAB9ATP53HTTSMN1; SMN2NPC1 | |
| SCHEMBL4727754 | 0.75 | EGFR (0.45) | RAB9ATP53HTTPDE10AMAPT | |
| SCHEMBL4728986 | 0.75 | EGFR (0.45) | RAB9ATP53HTTPDE10AMAPT | |
| SCHEMBL6000263 | 0.74 | EGFR (0.46) | SMN1; SMN2 | |
| SCHEMBL30000483 | 0.74 | ENPP1 (0.59) | SMN1; SMN2PDE10A | |
| SCHEMBL241727 | 0.73 | EGFR (0.58) | SMN1; SMN2 | |
| SCHEMBL30555608 | 0.73 | PDGFRB (0.65) | HTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL5682691 | 0.72 | ENPP1 (0.48) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |