Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729633 | 0.94 | EGFR (0.51) | RAB9AEGFRPDE10AABCB1CYP3A4 | |
| SCHEMBL4728986 | 0.90 | EGFR (0.45) | RAB9AEGFRPDE10AABCB1CYP3A4 | |
| SCHEMBL4727754 | 0.90 | EGFR (0.45) | RAB9AEGFRPDE10AABCB1CYP3A4 | |
| SCHEMBL4728717 | 0.80 | RAB9A (0.52) | RAB9APDE10ATP53HTTMAPT | |
| SCHEMBL4726586 | 0.77 | PDE10A (0.44) | EGFRPDE10AATMKIT | |
| SCHEMBL4725040 | 0.77 | PDE10A (0.44) | EGFRPDE10AATMKIT | |
| SCHEMBL4726982 | 0.76 | KIT (0.59) | EGFRPDE10ACYP3A4ATMMAPT | |
| SCHEMBL4728758 | 0.75 | RAB9A (0.53) | RAB9APDE10ATP53HTTMAPT | |
| SCHEMBL4726967 | 0.74 | PDE10A (0.52) | PDE10A | |
| SCHEMBL4726394 | 0.74 | PDE10A (0.52) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |