Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11332310 | 0.84 | KMT2A (0.73) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL13390947 | 0.83 | KMT2A (0.63) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL6857920 | 0.80 | KMT2A (0.73) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL11758088 | 0.80 | KMT2A (0.58) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL11758703 | 0.80 | KMT2A (0.58) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL1509271 | 0.80 | KMT2A (0.58) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL1745798 | 0.79 | KMT2A (0.71) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL175272 | 0.79 | MEN1 (0.71) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL113558 | 0.79 | MEN1 (0.71) | KMT2AMEN1KCNMA1NPC1PDK1 | |
| SCHEMBL6377318 | 0.79 | KMT2A (0.71) | KMT2AMEN1KCNMA1NPC1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032060-A1 | 4-BENZIMIDAZ0LYL-6-M0RPH0LIN0-2-PIPERAZINYLPYRIMIDINE DERIVATIVES AS P13K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032041-A1 | PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST PI3K ENZYMES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032077-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |