Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11758703 | 1.00 | KMT2A (0.58) | KMT2AMEN1PHGDHRAB9AGAA | |
| SCHEMBL11758088 | 1.00 | KMT2A (0.58) | KMT2AMEN1PHGDHRAB9AGAA | |
| Quinoline SCHEMBL11096417 | 0.86 | NPC1 (0.51) | KMT2AMEN1PHGDHRAB9AGAA | |
| Isoquinoline SCHEMBL10997368 | 0.86 | NPC1 (0.46) | KMT2AMEN1PHGDHRAB9AGAA | |
| Cadaverine Tartrate SCHEMBL28015425 | 0.82 | CYP1A2 (0.56) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11332310 | 0.80 | KMT2A (0.73) | KMT2AMEN1PHGDHRAB9AGAA | |
| SCHEMBL4729142 | 0.80 | KMT2A (0.63) | KMT2AMEN1PHGDHRAB9AGAA | |
| SCHEMBL13390947 | 0.80 | KMT2A (0.63) | KMT2AMEN1PHGDHRAB9AGAA | |
| SCHEMBL175272 | 0.79 | MEN1 (0.71) | KMT2AMEN1PHGDHRAB9AGAA | |
| SCHEMBL113558 | 0.79 | MEN1 (0.71) | KMT2AMEN1PHGDHRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4556712-A | OPTICAL RESOLUTION THROUGH SALT FORMATION AND SOLUBILITY | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1985-12-03 | — | — | US | claimed |
| EP-0079383-A4 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION. | US SECRETARY UNITED STATES DEP (US) | 1984-01-12 | — | — | EP | claimed |
| EP-0079383-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1983-05-25 | — | — | EP | claimed |
| WO-1982004049-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | US HEALTH (US) | 1982-11-25 | — | — | WO | claimed |
| US-8158796-B2 | Process for the preparation of Rho-kinase inhibitor compounds | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| EP-2291077-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | Inspire Pharmaceuticals, Inc. (US) | 2011-03-09 | — | — | EP | disclosed |
| EP-1638970-B1 | PYRID (2, 1-A) - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-01-28 | — | — | US | disclosed |
| WO-2009154940-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| US-7122555-B2 | Pyrido [2,1-a] isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1638970-A1 | PYRID (2, 1-A) - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000848-A1 | PYRIDO` 2, 1-A - ISOQUINOLINE DERIVATIVES AS DPP-IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |
| US-4410700-A | Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0079383-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1983-05-25 | — | — | EP | disclosed |
| WO-1982004049-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | US HEALTH (US) | 1982-11-25 | — | — | WO | disclosed |
| US-4162316-A | ANALGESICS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1979-07-24 | — | — | US | disclosed |
| US-4105695-A | LEARNING ENHANCEMENT, IMPROVES MENTAL ALERTNESS OF GERIATRICS | BRISTOL-MYERS COMPANY (US) | 1978-08-08 | — | — | US | disclosed |
| US-4080453-A | ANALGESICS, ANTITUSSIVE | DAINIPPON PHARMACEUTICAL CO., LTD. (JA) | 1978-03-21 | — | — | US | disclosed |
| US-4034113-A | Treatment of senile geriatric patients to restore performance | SHULGIN ALEXANDER T | 1977-07-05 | — | — | US | disclosed |
| US-3988456-A | ANALGESICS, ANTITUSSIVE | DAINIPPON PHARMACEUTICAL CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | KMT2A 2945/4885MEN1 2053/4885PHGDH 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.