Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729066 | 0.93 | ROCK2 (0.50) | L3MBTL1CYP3A4ROCK2CYP2D6CYP2C9 | |
| SCHEMBL4729229 | 0.91 | MEN1 (0.52) | MEN1KMT2AHDAC1NAMPTROCK2 | |
| SCHEMBL4727856 | 0.90 | MEN1 (0.45) | MEN1KMT2AL3MBTL1NR1H4NPC1 | |
| SCHEMBL4781615 | 0.85 | HPGD (0.51) | MEN1KMT2ANPC1RAB9ATSHR | |
| SCHEMBL4727301 | 0.82 | STIM1 (0.46) | MEN1KMT2ANPC1RAB9ASTIM1 | |
| SCHEMBL4727417 | 0.82 | STIM1 (0.44) | MEN1KMT2ANR1H4STIM1ORAI1 | |
| SCHEMBL4727073 | 0.81 | MAPK14 (0.48) | RAF1BRAF | |
| SCHEMBL4728221 | 0.80 | HPGD (0.48) | MEN1KMT2AL3MBTL1CYP1A2TSHR | |
| SCHEMBL4727373 | 0.78 | RAF1 (0.47) | RAF1BRAFRXFP1 | |
| SCHEMBL4726226 | 0.77 | RAF1 (0.46) | MEN1KMT2ANPC1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |