Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727073 | 0.88 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL4728217 | 0.84 | RAF1 (0.40) | — | |
| SCHEMBL4728367 | 0.84 | MAPK14 (0.50) | HPGDKMT2ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4727373 | 0.82 | RAF1 (0.47) | MAPK14 | |
| SCHEMBL4725920 | 0.81 | EGLN1 (0.48) | HPGDKMT2ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4729229 | 0.80 | MEN1 (0.52) | KMT2ASMN1; SMN2ROCK2MEN1 | |
| SCHEMBL4727856 | 0.80 | MEN1 (0.45) | KMT2ASMN1; SMN2TSHRL3MBTL1CYP1A2 | |
| SCHEMBL4729418 | 0.80 | MEN1 (0.44) | KMT2ASMN1; SMN2TSHRL3MBTL1CYP2C9 | |
| SCHEMBL4727070 | 0.80 | RAF1 (0.46) | — | |
| SCHEMBL4409369 | 0.79 | RAB9A (0.51) | HPGDKMT2ASMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |