Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265390 | 0.85 | MAPT (0.55) | NFKB1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7455794 | 0.82 | CA1 (0.56) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL6561859 | 0.82 | CA1 (0.56) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL20566331 | 0.82 | CA1 (0.49) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL5712170 | 0.81 | CA1 (0.55) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL69543 | 0.77 | NFKB1 (0.75) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL459291 | 0.77 | NFKB1 (0.75) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL31197561 | 0.77 | NFKB1 (0.75) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL11206640 | 0.77 | NFE2L2 (0.47) | MAPTMEN1KMT2ATDP1NPC1 | |
| SCHEMBL309761 | 0.77 | PTGER3 (0.63) | CA1CA2NFKB1CA4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033466-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PRE. LTD. (SG) | 2008-03-20 | — | — | WO | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |