Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482540 | 0.88 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2TEKMAPT | |
| SCHEMBL4728324 | 0.88 | EGFR (0.48) | RAB9ASMN1; SMN2TEKMAPTRAF1 | |
| SCHEMBL4728013 | 0.86 | RAF1 (0.42) | TEKRAF1BRAF | |
| SCHEMBL4725070 | 0.86 | TEK (0.46) | TEKRAF1BRAF | |
| SCHEMBL4726247 | 0.84 | RAF1 (0.43) | TEKRAF1BRAF | |
| SCHEMBL4565711 | 0.84 | TEK (0.41) | RAB9ANPC1SMN1; SMN2TEKMAPT | |
| SCHEMBL4726798 | 0.82 | RAF1 (0.42) | TEKRAF1BRAF | |
| SCHEMBL4725698 | 0.82 | RAF1 (0.48) | TEKRAF1BRAFNR1H4 | |
| SCHEMBL4417839 | 0.81 | MAPK14 (0.45) | RAB9ANPC1SMN1; SMN2TEKMAPT | |
| SCHEMBL4725060 | 0.81 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2TEKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |