SCHEMBL4729615

SCHEMBL4729615

NC(=O)C(=Cc1ccco1)C(N)=O

nearest known ligand 0.80

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.80
KMT2A Q03164 5/20 0.80
TDP1 Q9NUW8 4/20 0.80
MEN1 O00255 4/20 0.80
POLB P06746 4/20 0.54
KDM4E B2RXH2 3/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
TSHR P16473 1/20 0.51
CYP2C19 P33261 1/20 0.51
GAA P10253 2/20 0.49
THRB P10828 1/20 0.49
RECQL P46063 1/20 0.49
HCAR2 Q8TDS4 1/20 0.48
ALDH1A1 P00352 2/20 0.48
MASP2 O00187 1/20 0.44
F2 P00734 1/20 0.44
ALOX5 P09917 1/20 0.44
PLA2G7 Q13093 1/20 0.42
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3196199 0.82 MAPT (0.70) MAPTKMT2ATDP1MEN1POLB
SCHEMBL9316158 0.80 MAPT (0.63) MAPTKMT2ATDP1MEN1POLB
SCHEMBL24691599 0.79 KMT2A (0.58) MAPTKMT2ATDP1MEN1POLB
SCHEMBL4450762 0.78 KMT2A (0.57) MAPTKMT2ATDP1MEN1POLB
SCHEMBL4450765 0.78 KMT2A (0.57) MAPTKMT2ATDP1MEN1POLB
SCHEMBL2989011 0.77
SCHEMBL20163171 0.76 MAPT (0.67) MAPTKMT2ATDP1MEN1POLB
SCHEMBL27465110 0.76 MAPT (0.71) MAPTKMT2ATDP1MEN1POLB
SCHEMBL9341963 0.75 KMT2A (0.54) MAPTKMT2ATDP1MEN1POLB
SCHEMBL9341959 0.75 KMT2A (0.54) MAPTKMT2ATDP1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2008088126-A FURYLMETHYLENE MALONAMIDE COMPOUND AND SALT THEREOF, ULTRAVIOLET LIGHT ABSORBER AND EXTERNAL PREPARATION FOR SKIN SHISEIDO CO LTD 2008-04-17 JP disclosed
WO-2008041525-A1 FURYLMETHYLENE MALONAMIDE COMPOUND AND SALT THEREOF, ULTRAVIOLET RAY ABSORBENT, AND EXTERNAL PREPARATION FOR SKIN SHISEIDO COMPANY LTD. (JP) 2008-04-10 WO disclosed