Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOK | Q9UQ07 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 6/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4730661 | 0.99 | MOK (0.52) | MOKNCF1CNR2PDE10AUSP2 | |
| SCHEMBL4732598 | 0.84 | CNR2 (0.65) | MOKCNR2CNR1 | |
| SCHEMBL4731636 | 0.84 | ALDH1A1 (0.56) | MOKNCF1PDE10AUSP2ALDH1A1 | |
| SCHEMBL4733439 | 0.77 | NPSR1 (0.59) | MOKNCF1USP2ALDH1A1MAPT | |
| SCHEMBL4732942 | 0.75 | MOK (0.51) | MOKNCF1CNR2PDE10AUSP2 | |
| SCHEMBL5241851 | 0.72 | NCF1 (0.64) | MOKNCF1USP2ALDH1A1MAPT | |
| SCHEMBL5093588 | 0.70 | NCF1 (1.00) | NCF1USP2ALDH1A1MAPTMETAP1 | |
| SCHEMBL4731630 | 0.70 | NCF1 (0.55) | MOKNCF1USP2ALDH1A1MAPT | |
| SCHEMBL19475310 | 0.70 | MOK (0.77) | MOKNCF1ALDH1A1MAPTMETAP1 | |
| SCHEMBL19475531 | 0.69 | MOK (1.00) | MOKPDE10AALDH1A1MAPTPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | claimed |
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |