Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798309 | 0.99 | MEN1 (0.44) | MEN1KMT2APRMT5WDR77KDM4E | |
| SCHEMBL4734109 | 0.86 | MEN1 (0.43) | MEN1KMT2A | |
| SCHEMBL4731445 | 0.85 | MEN1 (0.46) | MEN1KMT2APRMT5WDR77KDM4E | |
| SCHEMBL4731973 | 0.85 | HPGD (0.39) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4731748 | 0.84 | POLB (0.45) | PRMT5WDR77 | |
| SCHEMBL4733147 | 0.83 | POLB (0.44) | PRMT5WDR77 | |
| SCHEMBL4734831 | 0.81 | PARG (0.36) | — | |
| SCHEMBL4734975 | 0.81 | MEN1 (0.45) | MEN1KMT2APRMT5WDR77KDM4E | |
| SCHEMBL4799653 | 0.81 | PARG (0.35) | — | |
| SCHEMBL4735297 | 0.80 | MEN1 (0.44) | MEN1KMT2APRMT5WDR77KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |