Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268908 | 0.89 | SIGMAR1 (0.79) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL4840680 | 0.88 | CCR2 (0.76) | SIGMAR1KMT2ADRD4 | |
| Hydrochloric Acid SCHEMBL29640479 | 0.88 | SIGMAR1 (0.77) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL5862113 | 0.86 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL2425554 | 0.86 | SIGMAR1 (0.78) | SIGMAR1KMT2ADRD4POLBL3MBTL1 | |
| SCHEMBL3075354 | 0.85 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL5124505 | 0.85 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| SCHEMBL29640480 | 0.85 | SIGMAR1 (0.81) | SIGMAR1POLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL21410212 | 0.84 | SIGMAR1 (0.76) | SIGMAR1KMT2ADRD4POLBL3MBTL1 | |
| SCHEMBL6177317 | 0.83 | SIGMAR1 (0.79) | SIGMAR1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032036-A1 | 6-BENZIMIDAZ0LYL-2-M0RPH0LIN0-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |