Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765787 | 0.91 | POLB (0.50) | EPHX2HDAC8ALDH1A1 | |
| SCHEMBL4853024 | 0.90 | ALOX15 (0.49) | EPHX2HDAC8MTNR1AMTNR1B | |
| SCHEMBL4736598 | 0.89 | EPHX2 (0.44) | EPHX2HDAC8MTNR1AMTNR1BCA12 | |
| SCHEMBL9443665 | 0.82 | ADRB3 (0.51) | ALDH1A1MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL9443694 | 0.82 | ADRB3 (0.51) | ALDH1A1MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL9443701 | 0.82 | ADRB3 (0.51) | ALDH1A1MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL7035289 | 0.81 | MTNR1A (0.53) | EPHX2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL5681677 | 0.81 | MTNR1A (0.53) | EPHX2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL7275241 | 0.81 | EPHX2 (0.47) | EPHX2MTNR1AMTNR1BCA12CA1 | |
| SCHEMBL4843025 | 0.81 | EPHX2 (0.47) | EPHX2MTNR1AMTNR1BCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |