Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681677 | 1.00 | MTNR1A (0.53) | MTNR1AMTNR1BADRB3ADRB1ALOX15 | |
| SCHEMBL4853024 | 0.91 | ALOX15 (0.49) | MTNR1AMTNR1BADRB3ADRB1ALOX15 | |
| SCHEMBL5679130 | 0.90 | MTNR1A (0.52) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL5722257 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL5722255 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL9443665 | 0.87 | ADRB3 (0.51) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL9443701 | 0.87 | ADRB3 (0.51) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL9443694 | 0.87 | ADRB3 (0.51) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL5681735 | 0.86 | ACHE (0.48) | MTNR1AMTNR1BADRB3ADRB1ACHE | |
| SCHEMBL5679215 | 0.85 | HDAC8 (0.53) | MTNR1AMTNR1BADRB3ADRB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292572-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094307-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2001-12-13 | — | — | WO | disclosed |