Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14223409 | 0.95 | PDK2 (0.33) | NPC1PDK2CYP11B1CYP11B2ABL1 | |
| SCHEMBL4730786 | 0.91 | NPC1 (0.36) | NPC1PFKFB3PFKFB4ABL1POLB | |
| SCHEMBL4729162 | 0.85 | CCR2 (0.36) | NPC1ABL1POLBNPSR1RAB9A | |
| SCHEMBL14223016 | 0.77 | SLC6A9 (0.34) | NPC1KDM4ENPSR1RAB9AKMT2A | |
| SCHEMBL1961431 | 0.76 | CACNA2D1 (0.41) | KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL4796389 | 0.75 | KDM4E (0.33) | NPC1KDM4ERAB9AALDH1A1 | |
| SCHEMBL4796398 | 0.75 | KDM4E (0.33) | NPC1KDM4ERAB9AALDH1A1 | |
| SCHEMBL4729550 | 0.74 | NPC1 (0.38) | NPC1ABL1POLBMCOLN3KDM4E | |
| SCHEMBL14223017 | 0.72 | KDM4E (0.33) | NPC1KDM4ENPSR1RAB9AKMT2A | |
| SCHEMBL1960202 | 0.71 | CYP2E1 (0.39) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |