Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789994 | 0.83 | L3MBTL1 (0.44) | L3MBTL1HTTRXFP1MEN1KMT2A | |
| SCHEMBL9910899 | 0.77 | CHEK1 (0.70) | CDK5CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL2133297 | 0.77 | KDM4C (0.45) | ALDH1A1KDM4C | |
| SCHEMBL4728474 | 0.77 | PDK1 (0.46) | CDK5CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL1563562 | 0.76 | KDM5A (0.48) | CDK5CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL2842932 | 0.76 | MAPT (0.48) | L3MBTL1ALDH1A1HTTMEN1KMT2A | |
| Methane SCHEMBL27733031 | 0.75 | KDM5A (0.47) | CDK5CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL2144329 | 0.74 | PDGFRA (0.44) | CDK5PDGFRATYRO3ALDH1A1HTT | |
| SCHEMBL2721702 | 0.74 | CHEK1 (0.54) | CDK5CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL22506702 | 0.73 | PDK1 (0.42) | CDK5CHEK1AURKACSNK1A1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |