Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22536415 | 0.83 | PDK1 (0.40) | PDK1PDK2MAPTL3MBTL1POLB | |
| SCHEMBL5074428 | 0.75 | ESR1 (0.40) | MAPTL3MBTL1POLBTDP1HCAR3 | |
| SCHEMBL9388063 | 0.75 | KDM4E (0.43) | MAPTL3MBTL1POLBKDM4EMEN1 | |
| Methane SCHEMBL27712687 | 0.73 | ESR1 (0.39) | MAPTL3MBTL1POLBTDP1HCAR3 | |
| SCHEMBL4730929 | 0.73 | CDK5 (0.41) | L3MBTL1CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL9389609 | 0.73 | KDM4C (0.50) | L3MBTL1POLBTDP1MEN1KMT2A | |
| SCHEMBL2133297 | 0.73 | KDM4C (0.45) | MAPTKDM4EKDM4CALDH1A1 | |
| SCHEMBL13106185 | 0.72 | CHRM4 (0.39) | PDK1PDK2ALOX15CHRM4 | |
| SCHEMBL1563562 | 0.71 | KDM5A (0.48) | MAPTKDM4ECHEK1AURKACSNK1A1 | |
| SCHEMBL3131503 | 0.71 | KDM4C (0.52) | POLBKDM4EMEN1KMT2AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260070910-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2026-03-12 | — | — | US | disclosed |
| US-20240300952-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2024-09-12 | — | — | US | disclosed |
| CN-111655692-B | Nitrogen-containing heterocyclic amide compound and medical application thereof | 日本烟草产业株式会社 | 2023-10-10 | — | — | CN | disclosed |
| US-20210284644-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2021-09-16 | — | — | US | disclosed |
| US-20210284644-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2021-09-16 | — | — | US | disclosed |
| EP-3747888-A1 | NITROGENATED HETEROCYCLIC AMIDE COMPOUND, AND USE THEREOF FOR MEDICAL PURPOSES | Japan Tobacco Inc. (JP) | 2020-12-09 | — | — | EP | disclosed |
| US-10800784-B2 | Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2020-10-13 | — | — | US | disclosed |
| US-10800784-B2 | Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2020-10-13 | — | — | US | disclosed |
| CN-111655692-A | Nitrogen-containing heterocyclic amide compound and medical application thereof | 日本烟草产业株式会社 | 2020-09-11 | — | — | CN | disclosed |
| WO-2019151274-A1 | NITROGENATED HETEROCYCLIC AMIDE COMPOUND, AND USE THEREOF FOR MEDICAL PURPOSES | 日本たばこ産業株式会社 | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800784-B2 | Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof | IDH2, PC, FH | PDK1 52/4885PDK2 9/4885MAPT 992/4885 |
| US-20240300952-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | IDH2, PC, FH | PDK1 52/4885PDK2 9/4885MAPT 992/4885 |
| US-20210284644-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | IDH2, PC, FH | PDK1 52/4885PDK2 9/4885MAPT 992/4885 |
| US-20260070910-A1 | NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF | PC, CS, IDH2 | PDK1 54/4885PDK2 37/4885MAPT 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.