Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730536 | 0.89 | ATR (0.43) | HTTMTORPIK3CAATRNPSR1 | |
| SCHEMBL4727905 | 0.87 | ATR (0.49) | HTTMTORPIK3CAATRNPSR1 | |
| SCHEMBL4727055 | 0.83 | PIK3CA (0.41) | HTTMTORPIK3CAATRNPSR1 | |
| SCHEMBL4794320 | 0.82 | PIK3CA (0.48) | HTTMTORPIK3CAPIK3R1NPSR1 | |
| SCHEMBL4730594 | 0.79 | AKT1 (0.44) | MTORPIK3CAPIK3R1ATRPIK3CD | |
| SCHEMBL4731787 | 0.78 | JAK2 (0.45) | MTORPIK3CAATRMAPTKMT2A | |
| SCHEMBL4727870 | 0.77 | PIK3CB (0.48) | MTORPIK3CAATRNPSR1TSHR | |
| SCHEMBL4726457 | 0.77 | PIK3CB (0.48) | MTORPIK3CAATRNPSR1TSHR | |
| SCHEMBL4728682 | 0.74 | TERT (0.43) | MTORPIK3CAATRCYP3A4PIK3CD | |
| SCHEMBL3719793 | 0.73 | MAPT (0.84) | HTTMTORPIK3CAPIK3R1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032077-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |