Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143220 | 0.90 | MAPT (0.45) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL1728318 | 0.82 | MAPT (0.55) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL4779360 | 0.81 | MAPT (0.62) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL1458894 | 0.80 | KDM4E (0.41) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL14291019 | 0.78 | KDM4E (0.36) | KDM4EHPGDHTTATM | |
| SCHEMBL4755031 | 0.77 | KDM4E (0.61) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL4755035 | 0.77 | KDM4E (0.61) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL4793397 | 0.77 | KDM4E (0.36) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL4793400 | 0.77 | KDM4E (0.36) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL3262134 | 0.76 | PLA2G2A (0.36) | KDM4EMAPTALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |