Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793400 | 1.00 | KDM4E (0.36) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4777606 | 0.94 | IKBKB (0.34) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4725145 | 0.94 | IKBKB (0.34) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL14291019 | 0.94 | KDM4E (0.36) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4140069 | 0.91 | KDM4E (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4140062 | 0.91 | KDM4E (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL14291286 | 0.88 | IKBKB (0.33) | PDE4DSYKSLC6A9IKBKB | |
| SCHEMBL4795076 | 0.88 | ALDH1A1 (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4795067 | 0.88 | ALDH1A1 (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4155397 | 0.87 | KDM4E (0.38) | KDM4EHTTATMPDE4DSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |