Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11505357 | 0.85 | MAPT (0.55) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL21633076 | 0.81 | ADRB2 (0.46) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL2925262 | 0.78 | TDP1 (0.48) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL32669352 | 0.77 | CA2 (0.32) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL4734190 | 0.76 | TDP1 (0.37) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL7871857 | 0.76 | MAPT (0.46) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL10980722 | 0.76 | GAA (0.46) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL3085307 | 0.76 | KDM4E (0.47) | GAAMAPTCA2CA1CA9 | |
| SCHEMBL11372198 | 0.74 | THRA (0.53) | CA2CA1GSK3BTHRATHRB | |
| SCHEMBL5981517 | 0.74 | MAPT (0.55) | GAAMAPTCA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008053158-A1 | INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| US-6099625-A | Ink composition | ZENECA LIMITED (GB) | 2000-08-08 | — | — | US | disclosed |