Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 6/20 | 0.74 |
| ▸ | METAP1 | P53582 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733334 | 0.85 | NCF1 (1.00) | NCF1METAP1HSD17B10KDM4EMAPT | |
| SCHEMBL5093588 | 0.82 | NCF1 (1.00) | NCF1METAP1HSD17B10KDM4EMAPT | |
| SCHEMBL27613419 | 0.82 | NCF1 (0.74) | NCF1HSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL2814765 | 0.81 | NCF1 (0.50) | NCF1METAP1MAPTALDH1A1GAA | |
| SCHEMBL14478814 | 0.81 | MOK (0.65) | NCF1METAP1KDM4EMAPTALDH1A1 | |
| SCHEMBL5093473 | 0.78 | NCF1 (0.64) | NCF1METAP1HSD17B10KDM4EMAPT | |
| SCHEMBL5241851 | 0.78 | NCF1 (0.64) | NCF1METAP1HSD17B10KDM4EMAPT | |
| SCHEMBL6159158 | 0.78 | EGFR (0.50) | NCF1METAP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2541848 | 0.78 | KDM4E (0.60) | NCF1HSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL24776296 | 0.78 | MAPT (0.47) | NCF1METAP1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |