Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MST1 | P26927 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31283928 | 1.00 | MAPT (0.47) | MAPTCYP1A2CYP2D6JAK2ABL1 | |
| SCHEMBL30818705 | 0.81 | HRH3 (0.41) | CYP2D6KMT2AMEN1NPC1RAB9A | |
| SCHEMBL4733419 | 0.78 | NCF1 (0.74) | MAPTNCF1KMT2AGAASMN1; SMN2 | |
| SCHEMBL31283496 | 0.75 | MAPT (0.42) | MAPTCYP1A2CYP2D6NCF1KMT2A | |
| SCHEMBL31283908 | 0.75 | PIK3CA (0.47) | MAPTCYP1A2JAK2ABL1INSR | |
| SCHEMBL24776906 | 0.75 | PIK3CA (0.47) | MAPTCYP1A2JAK2ABL1INSR | |
| SCHEMBL189922 | 0.75 | SMN1; SMN2 (0.49) | MAPTCYP1A2JAK2ABL1INSR | |
| SCHEMBL24776656 | 0.74 | KMT2A (0.42) | MAPTCYP1A2CYP2D6NCF1KMT2A | |
| SCHEMBL31284037 | 0.74 | KMT2A (0.42) | MAPTCYP1A2CYP2D6NCF1KMT2A | |
| SCHEMBL23755331 | 0.73 | PIK3CA (0.47) | MAPTCYP1A2CYP2D6JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256299-A1 | 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | disclosed |