Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732463 | 0.90 | MEN1 (0.46) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4732132 | 0.86 | KMT2A (0.43) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4732699 | 0.86 | SCD (0.48) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5102741 | 0.74 | SLC6A7 (0.51) | KDM4EALDH1A1SLC6A7CNR1CNR2 | |
| SCHEMBL4732472 | 0.74 | ALDH1A1 (0.47) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4730349 | 0.74 | SLC6A7 (0.43) | MEN1KMT2AKDM4ESLC6A7CNR1 | |
| SCHEMBL4731925 | 0.74 | CNR1 (0.49) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5090496 | 0.73 | MALT1 (0.45) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4732131 | 0.73 | ALDH1A1 (0.46) | SCDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14175660 | 0.73 | SLC6A7 (0.44) | SCDMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008058064-A1 | AMINE-LINKED MULTICYCLIC COMPOUNDS AS INHIBITORS OF THE PROLINE TRANSPORTER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | claimed |
| WO-2008058064-A1 | AMINE-LINKED MULTICYCLIC COMPOUNDS AS INHIBITORS OF THE PROLINE TRANSPORTER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |