Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449722 | 0.97 | MAPT (0.38) | HTR2AHTR2CHTR2BMAPTHSD17B10 | |
| SCHEMBL5126377 | 0.79 | HTR2A (0.33) | HTR2AHTR2CHTR2BMAPTHSD17B10 | |
| SCHEMBL23792086 | 0.78 | MAPT (0.37) | MAPTHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL20899427 | 0.74 | HTR2A (0.33) | HTR2AHTR2CHTR2BMAPTHSD17B10 | |
| SCHEMBL30503607 | 0.71 | MAPT (0.47) | HTR2AHTR2CHTR2BMAPTHSD17B10 | |
| SCHEMBL9452622 | 0.71 | MAPT (0.47) | HTR2AHTR2CHTR2BMAPTHSD17B10 | |
| SCHEMBL20898072 | 0.69 | ALDH1A1 (0.38) | HTR2AHTR2CHTR2BMAPTALDH1A1 | |
| SCHEMBL8263271 | 0.67 | PARP1 (0.34) | HTR2C | |
| SCHEMBL6440408 | 0.67 | CYP1A2 (0.38) | MAPTALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL17144450 | 0.67 | ADRA1A (0.37) | HTR2CHTR2BMAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |