Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595046 | 0.85 | IDO1 (0.42) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL6931451 | 0.80 | IDO1 (0.52) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL31048 | 0.80 | IDO1 (0.69) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL31290863 | 0.80 | IDO1 (0.69) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL8162137 | 0.80 | TAAR1 (0.44) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL410908 | 0.78 | L3MBTL1 (0.52) | IDO1TAAR1MAPTHPGD | |
| SCHEMBL28990663 | 0.77 | IDO1 (0.48) | IDO1ABCB1TAAR1CHRM2CHRM1 | |
| SCHEMBL648491 | 0.77 | IDO1 (0.44) | IDO1TAAR1CHRM2CHRM1CA12 | |
| SCHEMBL7959739 | 0.75 | L3MBTL1 (0.58) | IDO1ABCB1ALDH1A1GAAMAPT | |
| SCHEMBL457980 | 0.74 | APOBEC3G (0.41) | IDO1TAAR1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |