Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.70 |
| ▸ | THRB | P10828 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | HRH2 | P25021 | 4/20 | 0.70 |
| ▸ | HRH1 | P35367 | 4/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.70 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491776 | 0.86 | HRH2 (0.83) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL5856363 | 0.85 | HRH2 (0.81) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL492212 | 0.85 | HRH3 (0.77) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL14287851 | 0.84 | HRH3 (0.63) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL492239 | 0.83 | HRH3 (0.78) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL3577355 | 0.83 | HRH3 (0.79) | HRH3ACHESLC6A2KCNH2 | |
| Iodide SCHEMBL11221395 | 0.82 | HRH2 (0.85) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL14287849 | 0.82 | GLA (0.61) | HRH3THRBALDH1A1LMNAHRH2 | |
| Dyclonine SCHEMBL25773 | 0.82 | THRB (1.00) | HRH3THRBALDH1A1LMNAHRH2 | |
| SCHEMBL29766083 | 0.82 | THRB (1.00) | HRH3THRBALDH1A1LMNAHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139564-A1 | SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
| WO-2008064036-A1 | SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139564-A1 | SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | HRH3, SLC6A4, HNMT | HRH3 1/4885THRB 329/4885ALDH1A1 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.