Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734214 | 0.85 | MAPK14 (0.43) | PDK1MAPK14BCL2A1CXCR2HSP90AA1 | |
| SCHEMBL4784324 | 0.85 | PDK1 (0.46) | PDK1MAPK14BCL2A1CXCR2ALDH1A1 | |
| SCHEMBL4738782 | 0.83 | MAPK14 (0.45) | PDK1MAPK14BCL2A1CXCR2KCNQ3 | |
| SCHEMBL4737107 | 0.80 | GAA (0.58) | PDK1MAPK14BCL2A1CXCR2GAA | |
| SCHEMBL3822748 | 0.79 | BCL2A1 (0.52) | PDK1MAPK14BCL2A1CXCR2KCNQ3 | |
| SCHEMBL4737244 | 0.79 | ME2 (0.41) | MAPK14CXCR2ALDH1A1TSHR | |
| SCHEMBL3066549 | 0.78 | BCL2A1 (0.47) | PDK1MAPK14BCL2A1KCNQ3KCNQ2 | |
| SCHEMBL3071604 | 0.75 | BCL2A1 (0.44) | PDK1BCL2A1KCNQ3KCNQ2KCNE1 | |
| SCHEMBL3065683 | 0.73 | BCL2A1 (0.42) | PDK1BCL2A1KCNQ3KCNQ2KCNE1 | |
| SCHEMBL8193274 | 0.70 | MAPK14 (0.42) | PDK1MAPK14CXCR2P2RX7HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |