Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 2/20 | 0.41 |
| ▸ | ME1 | P48163 | 2/20 | 0.41 |
| ▸ | ME3 | Q16798 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737954 | 0.88 | KDM4E (0.45) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL4735615 | 0.88 | MAPK14 (0.45) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL4736473 | 0.86 | OPRM1 (0.41) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL4738239 | 0.83 | TSHR (0.49) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL3830332 | 0.83 | MEN1 (0.45) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL4738924 | 0.82 | OPRM1 (0.40) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL3823112 | 0.82 | RAB9A (0.52) | ME2ME1ME3ALDH1A1HTR1A | |
| SCHEMBL3823632 | 0.81 | L3MBTL1 (0.45) | ME2ME1ME3KDM4EALDH1A1 | |
| SCHEMBL3825171 | 0.81 | RAB9A (0.53) | ME2ME1ME3HTR1ADRD2 | |
| SCHEMBL8177578 | 0.81 | OPRM1 (0.45) | ME2ME1ME3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |