Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734738 | 0.91 | MAPT (0.59) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL4733395 | 0.82 | MAPT (0.58) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL4736051 | 0.82 | ITGB1 (0.54) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL4786625 | 0.81 | TDP1 (0.49) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL4733108 | 0.79 | ITGA4 (0.50) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3823774 | 0.79 | ITGA4 (0.50) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8250813 | 0.78 | MAPT (0.49) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL12193561 | 0.78 | MAPT (0.49) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL7880521 | 0.77 | MAPT (0.48) | MAPTNPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL3815413 | 0.76 | ALDH1A1 (0.50) | MAPTALDH1A1CTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064823-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | claimed |
| WO-2008064823-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | disclosed |