Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339173 | 0.76 | MAPT (0.77) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL4797498 | 0.75 | KDM4E (0.42) | GRM1GAAMEN1KMT2AMAPT | |
| SCHEMBL3341175 | 0.75 | GRM1 (0.59) | GRM1GAAMEN1KMT2AMAPT | |
| SCHEMBL4798176 | 0.73 | GRM1 (0.55) | GRM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4801351 | 0.73 | GRM1 (0.57) | GRM1MEN1KMT2AMAPTMAPK14 | |
| SCHEMBL4798879 | 0.72 | NPC1 (0.59) | GRM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4797456 | 0.71 | GRM1 (0.48) | GRM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4782600 | 0.70 | GRM1 (0.51) | GRM1GAAMEN1KMT2AMAPT | |
| SCHEMBL4794786 | 0.70 | KMT2A (0.68) | GRM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4795401 | 0.68 | GRM1 (0.61) | GRM1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |