SCHEMBL4734285

SCHEMBL4734285

CC(=O)c1cccc(C(=O)O)c1[N+](=O)[O-]

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
ALDH1A1 P00352 5/20 0.45
TDP1 Q9NUW8 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.43
ALOX15 P16050 1/20 0.43
AKR1C3 P42330 2/20 0.43
AKR1C2 P52895 2/20 0.43
PKM P14618 1/20 0.42
TP53 P04637 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPK1 P28482 1/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7647318 0.92 TSHR (0.49) TSHRALDH1A1TDP1AKR1C3AKR1C2
SCHEMBL1497989 0.90 TSHR (0.60) TSHRALDH1A1TDP1L3MBTL1ALOX15
SCHEMBL28171346 0.88 TSHR (0.58) TSHRALDH1A1TDP1L3MBTL1ALOX15
SCHEMBL30490414 0.88 TSHR (0.58) TSHRALDH1A1TDP1L3MBTL1ALOX15
SCHEMBL27771692 0.88 TSHR (0.58) TSHRALDH1A1TDP1L3MBTL1ALOX15
Ethylene SCHEMBL29290025 0.86 TSHR (0.56) TSHRALDH1A1TDP1L3MBTL1ALOX15
SCHEMBL2572950 0.83 ALDH1A1 (0.64) TSHRALDH1A1TDP1MEN1KMT2A
SCHEMBL4469803 0.83 GPR35 (0.56) TSHRALDH1A1TDP1L3MBTL1MEN1
Ethylene Glycol SCHEMBL29290024 0.82 TSHR (0.53) TSHRALDH1A1TDP1L3MBTL1ALOX15
SCHEMBL14854036 0.81 MAPT (0.45) TSHRALDH1A1TDP1TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008054454-A2 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF AS ANTIVIRAL AGENTS TRANSTECH PHARMA, INC. (US) 2008-05-08 WO disclosed