Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738465 | 0.78 | — | — | |
| SCHEMBL4736793 | 0.73 | PRKCI (0.42) | — | |
| SCHEMBL29797722 | 0.69 | HTR3A (0.39) | NOTUM | |
| SCHEMBL14571701 | 0.69 | QDPR (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14758337 | 0.66 | MAPT (0.36) | NOTUM | |
| SCHEMBL12330400 | 0.66 | NOTUM (0.36) | NOTUM | |
| SCHEMBL15427984 | 0.66 | CYP3A4 (0.39) | NOTUM | |
| SCHEMBL8363222 | 0.64 | HTR2A (0.36) | NOTUMPDE4BSLC5A1SLC5A2 | |
| SCHEMBL23505785 | 0.63 | NOTUM (0.49) | NOTUMPDE4A | |
| SCHEMBL8363230 | 0.62 | ALDH1A1 (0.38) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |