Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PPOX | P50336 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738402 | 0.87 | LTA4H (0.37) | MAOBHTR1AHTR1BMAPTLTA4H | |
| SCHEMBL4678195 | 0.77 | HTT (0.36) | HTTRECQLCSNK2A1THRBALDH1A1 | |
| SCHEMBL4738930 | 0.76 | HTR2C (0.38) | MAOBHTR1AMAPTKMT2APPOX | |
| SCHEMBL19795480 | 0.75 | LTA4H (0.39) | MAOBHTR1AHTR1BMAPTLTA4H | |
| SCHEMBL17433278 | 0.75 | GPR84 (0.50) | HTTRECQLCSNK2A1KDM4EMAOB | |
| SCHEMBL4741234 | 0.75 | GSTP1 (0.36) | HTTMAOBKAT6ACA12CA1 | |
| SCHEMBL4734966 | 0.73 | PARP10 (0.40) | — | |
| SCHEMBL26016388 | 0.72 | MAOB (0.36) | HTTRECQLCSNK2A1KDM4ETHRB | |
| SCHEMBL15771826 | 0.72 | CSNK2A1 (0.43) | HTTCSNK2A1KDM4ETHRBALDH1A1 | |
| SCHEMBL7679832 | 0.71 | MAOB (0.43) | MAOBHTR1AHTR1BMAPTLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343775-B1 | PIPERAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-04 | — | — | EP | claimed |