Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CCR9 | P51686 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958369 | 0.85 | CYP4F2 (0.61) | TSHRSMN1; SMN2CYP4F2CYP4A11P4HTM | |
| SCHEMBL7886665 | 0.83 | ALDH1A1 (0.52) | TSHRSMN1; SMN2GAACYP4F2CYP4A11 | |
| SCHEMBL15820303 | 0.82 | CYP11B1 (0.48) | TSHRCYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL5760402 | 0.82 | KDM4E (0.47) | SMN1; SMN2CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL20037758 | 0.82 | CYP11B1 (0.43) | CYP11B1CYP11B2ADRB2ADRB1CYP4F2 | |
| SCHEMBL3629544 | 0.82 | F2 (0.55) | CYP11B1CYP11B2ADRB2ADRB1P4HTM | |
| SCHEMBL990694 | 0.81 | TSHR (0.64) | TSHRSMN1; SMN2P4HTMLMNA | |
| SCHEMBL9105603 | 0.81 | TSHR (0.43) | TSHRCYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL12295789 | 0.81 | SMN1; SMN2 (0.55) | TSHRSMN1; SMN2GAAP4HTMHDAC1 | |
| SCHEMBL1410550 | 0.81 | CYP4F2 (0.42) | CYP11B1CYP11B2ADRB2ADRB1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0070185-B1 | PREPARATION OF LOWER ALKYL 2-FORMYL-3-(6-METHYL-3-PYRIDINYL)-PROPIONATES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-10 | — | — | EP | claimed |
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |
| WO-2014104235-A1 | 1,2,4-TRIS-SUBSTITUTED BENZENE COMPOUND AND METHOD FOR PRODUCING SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT | 東ソー株式会社 (JP) | 2014-07-03 | — | — | WO | disclosed |
| US-8466154-B2 | Methods and compositions related to wrapping of dehydrons | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-18 | — | — | US | disclosed |
| US-20130131076-A1 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-23 | — | — | US | disclosed |
| WO-2008070350-A9 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | UNIV TEXAS (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008070350-A2 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-06-12 | — | — | WO | disclosed |
| EP-0206294-B1 | ALKYL ESTERS OF 3-HYDROXY-3-(2-METHYL-5-PYRIDYL)-PROPIONIC ACID | LONZA AG (CH) | 1990-05-16 | — | — | EP | disclosed |
| US-4723017-A | Process for preparing 3-hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters | LONZA LTD. (CH) | 1988-02-02 | — | — | US | disclosed |
| US-4687856-A | 3-hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters | LONZA LTD. (CH) | 1987-08-18 | — | — | US | disclosed |
| EP-0206294-A1 | Alkyl esters of 3-hydroxy-3-(2-methyl-5-pyridyl)-propionic acid | LONZA AG (CH) | 1986-12-30 | — | — | EP | disclosed |
| EP-0070185-B1 | PREPARATION OF LOWER ALKYL 2-FORMYL-3-(6-METHYL-3-PYRIDINYL)-PROPIONATES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-10 | — | — | EP | disclosed |
| EP-0070185-A1 | Preparation of lower alkyl 2-formyl-3-(6-methyl-3-pyridinyl)-propionates | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131076-A1 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | DKK1, HPN, OSBP2 | TSHR 4461/4885SMN1; SMN2 4521/4885CCR9 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.