Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10662120 | 0.87 | HDAC1 (0.51) | HDAC1HDAC6KDM4EKMT2AMEN1 | |
| SCHEMBL29939457 | 0.87 | HDAC1 (0.51) | HDAC1HDAC6KDM4EKMT2AMEN1 | |
| SCHEMBL5271037 | 0.83 | HDAC1 (0.51) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL10812902 | 0.82 | HDAC1 (0.58) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL10349630 | 0.81 | HDAC1 (0.45) | HDAC1HDAC6KDM4EKMT2AMEN1 | |
| SCHEMBL27787011 | 0.79 | SMN1; SMN2 (0.54) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL3539766 | 0.79 | POLB (0.53) | HDAC1HDAC6KDM4EKMT2AMEN1 | |
| SCHEMBL30574349 | 0.78 | MAPK1 (0.67) | HDAC1HDAC6KDM4EKMT2AMEN1 | |
| SCHEMBL2632670 | 0.78 | HDAC1 (0.56) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL64763 | 0.78 | MAPK1 (0.67) | HDAC1HDAC6KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466154-B2 | Methods and compositions related to wrapping of dehydrons | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-18 | — | — | US | disclosed |
| US-20130131076-A1 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-23 | — | — | US | disclosed |
| WO-2008070350-A9 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | UNIV TEXAS (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008070350-A2 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-06-12 | — | — | WO | disclosed |
| US-4723017-A | Process for preparing 3-hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters | LONZA LTD. (CH) | 1988-02-02 | — | — | US | disclosed |
| US-4687856-A | 3-hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters | LONZA LTD. (CH) | 1987-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131076-A1 | METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS | DKK1, HPN, OSBP2 | HDAC1 4565/4885HDAC6 3993/4885KDM4E 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.