Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13254898 | 0.97 | MAPT (0.49) | MAPTL3MBTL1SRD5A2S1PR5KDM4E | |
| SCHEMBL2287562 | 0.94 | MAPT (0.51) | MAPTL3MBTL1SRD5A2S1PR5KDM4E | |
| SCHEMBL3833565 | 0.88 | DRD2 (0.40) | L3MBTL1NPC1RAB9AKMT2AHRH2 | |
| SCHEMBL361871 | 0.83 | AKT1 (0.42) | MAPTL3MBTL1SRD5A2S1PR5STS | |
| SCHEMBL14876685 | 0.83 | L3MBTL1 (0.46) | MAPTL3MBTL1SRD5A2S1PR5KDM4E | |
| SCHEMBL14876686 | 0.83 | L3MBTL1 (0.46) | MAPTL3MBTL1SRD5A2S1PR5KDM4E | |
| SCHEMBL3836833 | 0.81 | CES2 (0.48) | RAB9ASSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL3617282 | 0.81 | MAPT (0.43) | MAPTL3MBTL1SRD5A2S1PR5KDM4E | |
| SCHEMBL12583792 | 0.80 | L3MBTL1 (0.41) | MAPTL3MBTL1SRD5A2S1PR5STS | |
| SCHEMBL2712662 | 0.80 | SSTR4 (0.53) | KDM4ESSTR4ALDH1A1HTTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604989-B2 | Imidazopyridazines as Akt kinase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-28 | — | — | US | disclosed |
| EP-2802586-B1 | SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS | BAYER IP GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| US-9260435-B2 | Substituted imidazopyrazines as Akt kinase inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-02-16 | — | — | US | disclosed |
| US-20150368250-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-24 | — | — | US | disclosed |
| US-9206185-B2 | Imidazopyridazines as Akt kinase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-08 | — | — | US | disclosed |
| EP-2694510-B1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | BAYER IP GMBH (DE) | 2015-10-14 | — | — | EP | disclosed |
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |
| US-20150005309-A1 | SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-01-01 | — | — | US | disclosed |
| EP-2802586-A1 | SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS | Bayer Intellectual Property GmbH (DE) | 2014-11-19 | — | — | EP | disclosed |
| EP-2104669-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2014-10-15 | — | — | EP | disclosed |
| EP-2694510-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | Bayer Intellectual Property GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| US-8614221-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2013-12-24 | — | — | US | disclosed |
| US-8536193-B2 | Inhibitors of AKT activity | MERCK SHARP & DOHME CORP. (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2299825-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2013104610-A1 | SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-18 | — | — | WO | disclosed |
| EP-2516435-A1 | INHIBITORS OF AKT ACTIVITY | Almac Discovery Limited (GB) | 2012-10-31 | — | — | EP | disclosed |
| US-8288407-B2 | Substituted naphthyridine compounds as inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2012-10-16 | — | — | US | disclosed |
| WO-2012136776-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |
| WO-2011077098-A9 | INHIBITORS OF AKT ACTIVITY | ALMAC DISCOVERY LIMITED (GB) | 2012-04-19 | — | — | WO | disclosed |
| WO-2008070041-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368250-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | PI4KA, PI4KB, PIK3CD | MAPT 2976/4885L3MBTL1 4547/4885SRD5A2 1972/4885 |
| US-20150005309-A1 | SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS | PIK3CA, PIK3CD, PI4KA | MAPT 2946/4885L3MBTL1 4715/4885SRD5A2 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.