Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | TYMS | P04818 | 1/20 | 0.62 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.61 |
| ▸ | TNKS | O95271 | 2/20 | 0.60 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621956 | 0.98 | PARP1 (0.96) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL8621967 | 0.98 | PARP1 (0.96) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL21968820 | 0.91 | PARP1 (0.83) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL11546086 | 0.79 | KDM4E (1.00) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL6695759 | 0.79 | TNKS2 (0.81) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL29535139 | 0.77 | KDM4E (0.66) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL17460813 | 0.77 | PARP1 (0.62) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL30704851 | 0.77 | PARP1 (0.62) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL7263029 | 0.77 | KDM4E (0.66) | PARP1TNKS2KDM4EALDH1A1MAPT | |
| SCHEMBL5199045 | 0.77 | TNKS2 (0.62) | PARP1TNKS2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 862 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025079090-A1 | SUBSTITUTED 4-HETEROATOM-ISOQUINOLONE COMPOUNDS, PROCESS OF PREPARATION AND APPLICATIONS THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2025-04-17 | — | — | WO | claimed |
| CN-119161331-A | Preparation method of degradation impurities in raltitrexed preparation | 浙江皓格药业有限公司 | 2024-12-20 | — | — | CN | claimed |
| CN-118090990-A | Preparation method of stable isotope labeled hypnone internal standard reagent | 谱同生物医药科技(常州)有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-117903125-A | Preparation method of raltitrexed | 无锡紫杉药业股份有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-117327060-A | Preparation method of intermediate impurity of raltitrexed | 无锡紫杉药业股份有限公司 | 2024-01-02 | — | — | CN | claimed |
| CN-116510024-A | Composition, preparation method and application thereof | 上海复东生物医药有限责任公司 | 2023-08-01 | — | — | CN | claimed |
| CN-111363027-B | Hypnone antigen and preparation method thereof | 杭州隆基生物技术有限公司 | 2022-02-22 | — | — | CN | claimed |
| EP-3542801-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES | Boehringer Ingelheim International GmbH (DE) | 2019-09-25 | — | — | EP | claimed |
| CN-106045922-A | 2-(Amino) methylquinazolin-4(3H)-one compound and preparation method and application thereof | 湘潭大学 | 2016-10-26 | — | — | CN | claimed |
| US-20160136180-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2016-05-19 | — | — | US | claimed |
| WO-2009024542-A2 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-26 | — | — | WO | claimed |
| EP-1641799-B1 | IMIDAZO-PYRIDAZINONE DERIVATIVES AND IMIDAZO-PYRIDONE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2008-03-12 | — | — | EP | claimed |
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | claimed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | claimed |
| US-20050026921-A1 | New imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-02-03 | — | — | US | claimed |
| US-6121452-A | REACTING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND WITH AN AROMATIC DICARBOXYLIC ACID OR AN ANHYDRIDE THEREOF IN AN ORGANIC SOLVENT IN THE PRESENCE OF AN UNSUBSTITUTED PHENOL OR NAPHTHOL OR MIXTURE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | claimed |
| US-5939568-A | Accelerated catalysis of olefinic epoxidations | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-08-17 | — | — | US | claimed |
| US-5874444-A | CONTROLLING CELL AGING | GERON CORPORATION (US) | 1999-02-23 | — | — | US | claimed |
| US-5830909-A | DIETETICS | AMERICAN CYANAMID COMPANY (US) | 1998-11-03 | — | — | US | claimed |
| US-5342950-A | Reacting a methyl-substituted heterocyclic compound with an anhydride of an aromatic dicarboxylic acid in an alkyl benzoate solvent | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160136180-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | PNP, ENTPD5, NUDT14 | PARP1 159/4885TNKS2 272/4885KDM4E 3292/4885 |
| US-20050026921-A1 | New imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions | DPP4, DPP3, DPP7 | PARP1 2203/4885TNKS2 2602/4885KDM4E 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.