Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.62 |
| ▸ | PARP1 | P09874 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884186 | 0.82 | KDM4E (0.64) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL29909366 | 0.79 | KDM4E (0.64) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL204726 | 0.79 | NPC1 (0.73) | RAB9ALMNASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3821179 | 0.79 | KDM4E (0.64) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL30289849 | 0.78 | KDM4E (0.74) | TNKS2PARP1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29839737 | 0.78 | RAB9A (0.56) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL10004573 | 0.78 | RAB9A (0.53) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL47352 | 0.77 | PARP1 (1.00) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL28275368 | 0.77 | KDM4E (0.60) | TNKS2PARP1RAB9AMAPTLMNA | |
| SCHEMBL29040044 | 0.76 | KDM4E (0.66) | RAB9AMAPTLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841746-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-ON COMPOUNDSFOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICITION AND EPILEPSY, THEIR PREPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-10 | — | — | EP | claimed |
| WO-2006072588-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-CN COMPOUNDS FOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICTION AND EPILEPSY, THEIR PREAPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2006-07-13 | — | — | WO | claimed |
| EP-1841746-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-ON COMPOUNDSFOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICITION AND EPILEPSY, THEIR PREPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006072588-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-CN COMPOUNDS FOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICTION AND EPILEPSY, THEIR PREAPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2006-07-13 | — | — | WO | disclosed |