SCHEMBL4735534

SCHEMBL4735534

CC(C)(CC(O)(CNc1cccc2[nH]ccc12)C(F)(F)F)C1=COC(Cc2ccccc2)O1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 9/20 0.47
PGR P06401 2/20 0.47
HTR1A P08908 2/20 0.33
DHPS P49366 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4628521 0.87 NR3C1 (0.39) NR3C1PGRDHPS
SCHEMBL4630426 0.79 NR3C1 (0.42) NR3C1PGR
SCHEMBL6405691 0.78 NR3C1 (0.41) NR3C1PGR
SCHEMBL6406150 0.78 IDO1 (0.36) NR3C1PGR
SCHEMBL4629928 0.78 NR3C1 (0.54) NR3C1PGR
SCHEMBL4628810 0.77 NR3C1 (0.46) NR3C1PGR
SCHEMBL6404388 0.76 NR3C1 (0.36) NR3C1PGR
SCHEMBL5802087 0.73 NR3C1 (0.40) NR3C1PGRDHPS
SCHEMBL4735535 0.71 NR3C1 (0.53) NR3C1PGRHTR1ADHPS
SCHEMBL6406027 0.69 NR3C1 (0.58) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008055709-A1 INDAZOLE AND INDOLE DERIVATIVES AS ANTI -INFLAMMATORY AGENTS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-05-15 WO disclosed