Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CTH | P32929 | 1/20 | 0.31 |
| ▸ | CBS | P35520 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230834 | 0.98 | ALDH1A1 (0.34) | BLMPMP22HSD17B10ALDH1A1MEN1 | |
| SCHEMBL18752950 | 0.86 | CA12 (0.37) | ALDH1A1PTGS2CA12CA1CA2 | |
| SCHEMBL2232094 | 0.83 | BLM (0.41) | BLMPMP22HSD17B10ALDH1A1MEN1 | |
| SCHEMBL397067 | 0.83 | BLM (0.41) | BLMPMP22HSD17B10ALDH1A1MEN1 | |
| SCHEMBL437092 | 0.82 | ALDH1A1 (0.46) | ALDH1A1PTGS1PTGS2CA12CA1 | |
| SCHEMBL28277555 | 0.82 | ALDH1A1 (0.46) | ALDH1A1PTGS1PTGS2CA12CA1 | |
| SCHEMBL1773954 | 0.82 | ALDH1A1 (0.46) | ALDH1A1PTGS1PTGS2CA12CA1 | |
| SCHEMBL439675 | 0.82 | ALDH1A1 (0.46) | ALDH1A1PTGS1PTGS2CA12CA1 | |
| SCHEMBL11792981 | 0.82 | ALDH1A1 (0.46) | ALDH1A1PTGS1PTGS2CA12CA1 | |
| SCHEMBL4736289 | 0.80 | TSHR (0.44) | BLMPMP22ALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075152-A1 | 1- [4- (SULFONYL) -PHENYL] -5- (BENZYL) -IH-I, 2, 4-TRIAZOL DERIVATIVES AS INHIBITORS OF CARBONIC ANHYDRASE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |