Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232094 | 0.88 | BLM (0.41) | TSHRLMNABLMKMT2AMEN1 | |
| SCHEMBL397067 | 0.88 | BLM (0.41) | TSHRLMNABLMKMT2AMEN1 | |
| SCHEMBL457635 | 0.88 | LMNA (0.44) | TSHRLMNABLMKMT2AMEN1 | |
| Methane SCHEMBL2013629 | 0.86 | LMNA (0.43) | TSHRLMNABLMKMT2AMEN1 | |
| Ethane SCHEMBL2012141 | 0.84 | ESR2 (0.42) | TSHRLMNABLMKMT2AMEN1 | |
| SCHEMBL399991 | 0.82 | ALDH1A1 (0.48) | TSHRLMNABLMKMT2AMEN1 | |
| SCHEMBL15721716 | 0.81 | TSHR (0.60) | TSHRLMNABLMKMT2ASLC22A6 | |
| SCHEMBL29211769 | 0.81 | TSHR (0.60) | TSHRLMNABLMKMT2ASLC22A6 | |
| SCHEMBL4735665 | 0.80 | BLM (0.33) | TSHRLMNABLMKMT2AMEN1 | |
| SCHEMBL2011462 | 0.80 | ALDH1A1 (0.52) | TSHRLMNABLMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075152-A1 | 1- [4- (SULFONYL) -PHENYL] -5- (BENZYL) -IH-I, 2, 4-TRIAZOL DERIVATIVES AS INHIBITORS OF CARBONIC ANHYDRASE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |