Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799779 | 0.73 | HRH4 (0.49) | HRH4 | |
| SCHEMBL4786930 | 0.72 | HRH4 (0.41) | HRH4TSHRUSP2MAPTNPSR1 | |
| SCHEMBL4786925 | 0.69 | HRH4 (0.41) | HRH4KDM4EMAPTNPSR1 | |
| SCHEMBL602061 | 0.66 | HRH4 (0.66) | HRH4TSHR | |
| SCHEMBL4786717 | 0.64 | KDM4E (0.48) | KDM4EALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL4735717 | 0.63 | HRH4 (0.68) | HRH4 | |
| SCHEMBL4738366 | 0.63 | HRH4 (0.44) | HRH4 | |
| SCHEMBL3682487 | 0.61 | KIT (0.47) | KDM4EALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL3319476 | 0.61 | KMT2A (0.47) | KDM4EALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL4137101 | 0.61 | L3MBTL1 (0.54) | ALDH1A1TSHRHPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074445-A1 | NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-26 | — | — | WO | disclosed |