Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738366 | 0.81 | HRH4 (0.44) | HRH4HRH3 | |
| SCHEMBL4786930 | 0.79 | HRH4 (0.41) | HRH4MAPTNPSR1 | |
| SCHEMBL4785138 | 0.79 | HRH4 (0.61) | HRH4HRH3 | |
| SCHEMBL4799288 | 0.74 | HRH4 (0.62) | HRH4HRH3 | |
| SCHEMBL3106388 | 0.70 | PTGES (0.51) | — | |
| SCHEMBL4735673 | 0.69 | HRH4 (0.42) | HRH4KDM4EMAPTNPSR1 | |
| SCHEMBL604593 | 0.66 | HRH4 (0.72) | HRH4HRH3 | |
| SCHEMBL4740059 | 0.66 | HRH4 (0.65) | HRH4HRH3 | |
| SCHEMBL4799779 | 0.66 | HRH4 (0.49) | HRH4HRH3 | |
| SCHEMBL4739108 | 0.66 | HRH4 (0.61) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074445-A1 | NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-26 | — | — | WO | disclosed |