Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7623012 | 0.96 | — | — | |
| Bicarbonate SCHEMBL5451762 | 0.96 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL5451766 | 0.96 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL37341 | 0.92 | CA5A (0.73) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL792399 | 0.92 | — | — | |
| Bicarbonate SCHEMBL4713896 | 0.92 | CA5A (0.73) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL27985234 | 0.88 | — | — | |
| Bicarbonate SCHEMBL2546787 | 0.88 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL28875779 | 0.88 | — | — | |
| Bicarbonate SCHEMBL10821992 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822388-B2 | Multi-component aqueous gel solution for control of delayed gelation timing and for resulting gel properties | SPI TECHNOLOGIES LLC (US) | 2014-09-02 | — | — | US | disclosed |
| WO-2008067138-A1 | MULTI-COMPONENT AQUEOUS GEL SOLUTION FOR CONTROL OF DELAYED GELATION TIMING AND FOR RESULTING GEL PROPERTIES | SPI TECHNOLOGIES, LLC (US) | 2008-06-05 | — | — | WO | disclosed |
| US-20080125334-A1 | Water soluble alkali metal silicate solution, a water dispersible polymer; and a water soluble initiator of a reactive carbonyl compounds; seal pipes in production or injection wells, pipelines, and utility conduits | REGENCY TECHNOLOGIES LLC | 2008-05-29 | — | — | US | disclosed |