Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7623012 | 1.00 | — | — | |
| Bicarbonate SCHEMBL5451762 | 1.00 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL4735765 | 0.96 | CA5A (0.61) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL4713896 | 0.96 | CA5A (0.73) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL792399 | 0.96 | — | — | |
| Bicarbonate SCHEMBL37341 | 0.96 | CA5A (0.73) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL2546787 | 0.92 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL28875779 | 0.92 | — | — | |
| Bicarbonate SCHEMBL27985234 | 0.92 | — | — | |
| Bicarbonate SCHEMBL10821992 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070000413-A1 | Inorganic lightweight insulator and process for preparing it | PARK CHOONGBUM | 2007-01-04 | — | — | US | claimed |