Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.73 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL792399 | 1.00 | — | — | |
| Bicarbonate SCHEMBL4713896 | 1.00 | CA5A (0.73) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL5451762 | 0.96 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL28875779 | 0.96 | — | — | |
| Bicarbonate SCHEMBL7623012 | 0.96 | — | — | |
| Bicarbonate SCHEMBL2546787 | 0.96 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL10821992 | 0.96 | — | — | |
| Bicarbonate SCHEMBL5451766 | 0.96 | CA5A (0.67) | CA5ACA5BCA1CA2CA9 | |
| Bicarbonate SCHEMBL27985234 | 0.96 | — | — | |
| Bicarbonate SCHEMBL11218048 | 0.92 | CA5A (0.61) | CA5ACA5BCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232257-A1 | Novel Method for Directly Nitration of OH-, SH-and NHR-Functions in Organic Molecules by Means of in Situ Generated Carbonic Acid Dinitrate | SYNOVO GMBH (DE) | 2012-09-13 | — | — | US | claimed |
| WO-2024138157-A1 | NOVEL IMIDAZOQUINOLINES WITH IMMUNOSTIMULATORY EFFECTS | SYNOVO GMBH (DE) | 2024-06-27 | — | — | WO | disclosed |
| US-20120232257-A1 | Novel Method for Directly Nitration of OH-, SH-and NHR-Functions in Organic Molecules by Means of in Situ Generated Carbonic Acid Dinitrate | SYNOVO GMBH (DE) | 2012-09-13 | — | — | US | disclosed |
| US-20120232257-A1 | Novel Method for Directly Nitration of OH-, SH-and NHR-Functions in Organic Molecules by Means of in Situ Generated Carbonic Acid Dinitrate | SYNOVO GMBH (DE) | 2012-09-13 | — | — | US | disclosed |
| WO-2011033392-A3 | NOVEL METHOD FOR DIRECTLY NITRATING OH-, SH- AND NHR-FUNCTIONS IN ORGANIC MOLECULES BY MEANS OF IN SITU GENERATED CARBONIC ACID DINITRATE | BURNET, MICHAEL (DE) | 2011-11-17 | — | — | WO | disclosed |
| WO-2011033392-A2 | NOVEL METHOD FOR DIRECTLY NITRATING OH-, SH- AND NHR-FUNCTIONS IN ORGANIC MOLECULES BY MEANS OF IN SITU GENERATED CARBONIC ACID DINITRATE | BURNET, MICHAEL (DE) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232257-A1 | Novel Method for Directly Nitration of OH-, SH-and NHR-Functions in Organic Molecules by Means of in Situ Generated Carbonic Acid Dinitrate | DECR1, DHRS9, DNTT | CA5A 1667/4885CA5B 1270/4885CA1 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.