Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | WNT3 | P56703 | 1/20 | 0.46 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205606 | 0.78 | CCR8 (0.56) | CCR8WNT3SFRP1ALDH1A1MAPT | |
| SCHEMBL15917691 | 0.78 | MAPT (0.74) | CCR8WNT3SFRP1ALDH1A1MAPT | |
| SCHEMBL4623414 | 0.78 | BRD4 (0.55) | CCR8WNT3SFRP1ALDH1A1MAPT | |
| SCHEMBL4734261 | 0.78 | HRH2 (0.51) | DRD2ADRA1DADRA1AADRA1BCCR8 | |
| SCHEMBL5502165 | 0.77 | CCR8 (0.48) | CCR8WNT3SFRP1ALDH1A1MAPT | |
| SCHEMBL4733356 | 0.77 | SFRP1 (0.52) | WNT3SFRP1SLC22A12ALOX5APFEN1 | |
| SCHEMBL3811344 | 0.76 | USP30 (0.70) | UCHL1USP30 | |
| SCHEMBL3806512 | 0.76 | USP30 (0.70) | UCHL1USP30 | |
| SCHEMBL4504762 | 0.76 | REN (0.46) | DRD2ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4504759 | 0.76 | REN (0.46) | DRD2ADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |